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In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)

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Research by Kwon and Park involving 32 white rabbits divided into four groups explored the extent of cartilage degeneration following exposure to a placebo, AOD 9604 alone, hyaluronic acid alone, or a combination of AOD 9604 and hyaluronic acid over a period of 4 to 7 weeks