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Nevertheless, caution is advised in patients with a history of cardiovascular disease

Explanations for this excess of men have been attributed to possible protective hormonal factors in women, the increased likelihood of men being exposed to putative risk factors, and the under recognition of older women in some population registries (Wijesekera and Leigh 2009)

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Benefits in research settings include dramatically enhanced endurance capacity, improved fat oxidation, better glucose metabolism, and exercise-mimetic effects
