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Epub 2010 Aug 20

This selectivity has made it a preferred compound for researchers studying isolated growth hormone signalling pathways

Ipamorelin activates the Gq-coupled calcium signaling pathway in somatotrophs, while GHRH analogs (like CJC-1295) activate the Gs-coupled cAMP pathway

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They were commonly combined ("CJC/Ipamorelin") for a synergistic effect on growth hormone output