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In short, samples were obtained from EGFR-mutant lung adenocarcinoma patients with acquired erlotinib resistance under Human Investigations Protocol #111000928 (Yale Cancer Center, New Haven, CT)
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found that lactylation competitively inhibits PARP1 acetylation, resulting in recovery of its ADP-ribosylation activity and promoting DNA repair (Sun et al., 2022a)
It is approved in over 30 countries for hepatitis B and C treatment and as an immune adjuvant
