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while glycan from LBD Asn 402 is oriented towards ATD and might interact with its lower lobe (Fig

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Specifically, canagliflozin exerts its protective effect on the kidneys by regulating the SIRT3/FoxO3a/catalase pathway to reduce oxidative stress, inhibiting EMT in the HSD-induced dahl salt-sensitive rat hypertensive renal injury model and Ang II-treated HK-2 cells
