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Funding This work was supported by the National Key Research and Development Program of China (Project No.2021YFC2100200) and the Research and Development Plan in Key Areas of Guangdong Province (grant number 2022B1111050002)

Proteomics and Histone Data Analysis Proteome raw files were searched with Proteome Discoverer software (v2.4, Thermo Scientific) using SEQUEST as a search engine and the SwissProt human database