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Front Pharmacol (2022) 13:806470

Screening techniques for DPN, such as the 10-g monofilament and assessment of touch, vibration sense, and ankle reflexes, have limitations, primarily detecting advanced neuropathy and missing early stages, especially those associated with small fiber abnormalities and neuropathic pain [14, 17,18,19,20,21,22]

Additionally, macrophages, natural killer cells, and mast cells also produce LL-37

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also, negative immunoreactivity for CD68 in the cytoplasm of tubular epithelial cells was found (Figure 8A)