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It has been shown that prolonged use of statins may induce the development of ALS-like syndrome and may increase ALS risk

presumably acetyl-CoA would still be needed for histone acetylation and the mevalonate pathway even if fatty acid synthesis activity is low

The goal of this article is to help you find the best strategies to work with your unique genetic makeup to improve kidney health

doi: 10.1016/j.jacc.2013.11.002

Because KAT6A contains multiple functional domains, it is possible that ARTHS variants may result in a truncated protein that retains acetyltransferase activity but lacks proteinprotein interaction domains that regulate this activity

Metabolite addback and inhibitor treatment experiments were performed in the media conditions listed with supplementation of the listed metabolite or drug with equal volumes of vehicle control unless otherwise specified