motor neurone disease glutathione transferase Therapeutic modulation of GSTO activity rescues FUS-associated neurotoxicity via deglutathionylation in ALS models Discovery of key mechanism in
Description
185 Besides, other MTHFD2 inhibitors have been reported, including DS18561882 and LY345899 in a substrate-based manner, and treatments based on them decrease cellular NADPH/NADP + ratio, increase cellular ROS levels, and impair tumorigenesis and metastasis
So the delivery of GPx3 to breast tumor tissues through hiPSC-MSCs or other methods may promote its expression, and reduce the influence of ROS on the progression of breast cancer accordingly, finally achieve the goal of treating breast cancer

pmid:15063794 20

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Wang W, Zhang X, Zhao N, Xu Z, Jin K, Jin Z
