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In human skin fibroblasts, Nrf2-driven antioxidant enzyme expression translated into: Reduced intracellular ROS Improved mitochondrial membrane potential Protection against senescence-associated cell damage [36] In human gingival and periodontal stem cells, Epitalon significantly reduced aging biomarkers such as p16 and p21, decreased ROS levels, and preserved mitochondrial function, even under stress [42]

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Adiponectin enhances insulin sensitivity and has anti-inflammatory actions (Khoramipour et al., 2021)

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Thiodepsipeptides can be synthesized in a similar manner, but instead of using Ser or Thr, Cys is incorporated