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Oct 13 2017;8(48):83370-83383

Pruritus characteristic of cirrhosis predominantly manifests as a central phenomenon, purportedly stemming from augmented release of -endorphin, Met-enkephalin, and endomorphin-1,2, which stimulate -receptors within nerve tissues

the vitamin D can be provided in the composition in an amount so as to provide, in a unit dosage or serving, from about 250 IU to about 6000 IU, or from about 500 IU to about 5000 IU, or from about 750 IU to about 2500 IU (e.g., about 1000 IU, about 2000 IU) of Vitamin D

12 Other studies have now shown high levels of TMAO are associated with high levels of creatinine, low levels of HDL, type 2 diabetes and kidney disease 13