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4 The multiscale anticancer mechanisms of SFN: beyond Nrf2 and HDAC inhibition While the activation of Nrf2-mediated antioxidant response and inhibition of HDACs represent well-established mechanisms underlying SFNs anticancer properties, emerging evidence reveals a far more complex pharmacological profile
It includes Vitamin E and C, glutathione (GSH), various carotenoids and flavonoids
Experimental investigations demonstrate the capability of the catalyst to convert GSH in GSSG
Carr AC, Zawari M
Another hypothesis is that residual or hormone-independent symptoms might be due to the autoimmune, inflammatory, and/or pro-oxidant processes in HT
Free Radical Research, 57 , 130139
