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10.1021/acs.jnatprod.5b00947 12 Bambini-JuniorV.ZanattaG.Della Flora NunesG.Mueller De MeloG.MichelsM.Fontes-DutraM.et al (2014)

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Clinical significance of this inhibition is demonstrated by the fact that inhibition of CYP3A4 by metformin results in reduced mitochondrial respiration leading to reductions in cancer cell growth

Vomiting, lethargy and weakness are the next most common presenting complaints, with diarrhea or constipation occurring less frequently