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The differentiation protocol utilized was developed and optimized from the published literatures 18,19,20,21 , specifically chosen for its capacity to generate iHLOs with high CYP enzyme activity, particularly CYP3A4, which is crucial for drug metabolism and toxicology evaluations

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Systemic and central amylin, amylin receptor signaling, and their physiological and pathophysiological roles in metabolism

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J Neurosci 28:50075017

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