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As a neurosurgeon, I have frequently observed the consequences of oxidative stress in traumatic brain injuries, ruptured intracranial aneurysms (widening of blood vessels), and other major insults to the brain, Joseph Maroon, clinical professor of neurological surgery at the University of Pittsburgh Medical Center, Pennsylvania, US, told Despite observed evidence, corroborated by autopsy studies of ageing brains and those with neurodegenerative disorders, data from clinical trials is imperative to support the glutathione deficiency and oxidative stress theory of AD

In this regard, it is noteworthy that calorie restriction is associated with increased longevity and reduced insulin/IGF activity in many species (81) albeit GH levels are increased by calorie restriction and fasting (82)

Another major factor in cognitive decline and mood disorders is oxidative stress, which is markedly attenuated through the synergistic action of exercise and polyphenols

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