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A more recent hypothesis postulates that high-dose folic acid redirects the active form of vitamin B12 in serum, i.e., holotranscobalamin, either toward the bone marrow to support reticulocyte synthesis that is induced by folic acid in B12-deficient patients, or into the urine in which it is excreted instead of being taken up and recycled into circulation through the kidneys (84)

Using plain sterile water may work short-term, but it lacks the preservative properties needed for multi-use and longer storage

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it is a single-use diluent meant to be used immediately after opening and not stored for reuse

this prevents metabolic bottlenecks that might occur if one B vitamin is lacking