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doi: 10.1172/JCI7817

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These mutants were biochemically analyzed, revealing an altered topology of the Ca 2+ -binding site, thus proposing the role of this region of CRP in its binding to A, with the authors ultimately concluding that CRP is a dual pattern recognition molecule and an antiamyloidogenic protein as well [126]

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The idea is straightforward

If you miss two consecutive weeks, you're essentially restarting the timeline from week 1