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Chelation therapy, including nonabsorbed agents, should be initiated at a low dose and then gradually titrated to recommended doses according to the individual's response, to avoid the patient's health deteriorating with metal redistribution, other physiological perturbations, or drug intolerance

At present, clinical trials of anti-ageing drugs targeting CVDs have not yet been initiated and remain largely confined to metabolic diseases or osteoarthritis
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In addition, two studies examining risk factors for transfusion-related acute lung injury (TRALI) found that chronic alcohol consumption was associated with the development of TRALI
