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The change was -2.7 [95% confidence interval (CI): -3.9, -1.5] in the mecobalamin 50 mg group and -4.6 [95% CI: -5.8, -3.4] in the placebo group, with a difference in change of 2.0 (95% CI: 0.4, 3.5

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PregS is a relatively potent positive allosteric modulator of NMDAR-mediated synaptic transmission, while pregnanolone sulfate is a relatively potent negative allosteric modulator of NMDAR-mediated glutamatergic neurotransmission (24, 35, 110)

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