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Another option is mechanical stimulation therapy, based on the sensitivity of the Piezo1 channel to mechanical stimulation, specific physical therapy or mechanical stimulation can be developed to regulate the activity of microglia by altering the mechanical properties of the microenvironment in the CNS, thereby promoting the clearance of A plaques

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Specifically, analyzed were the affected brain areas (04), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), and hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) as follows (score 0 indicates no histopathologic change): score 1: small, patchy, complete, or incomplete infarcts (10% of the area affected)

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