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Inulin treatment promotes the infiltration CD8 + T cells in tumors of several mouse models, and induces a shift to a pro-inflammatory tumor microenvironment (6870)

doi: 10.1186/1465-9921-6-79 87 AyalaAMuozMFArgellesS

Proteger da luz do calor e da umidade

1955;40(5 Pt 2):100110

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Using in vitro tag-free mature AIF-based biochemical assays, cellular loss-of-function and gain-of-function studies, and AIF3 splicing models in vivo, we further found that full-length mature AIF was a mammalian mitochondrial complex I alternative NAD(P)H dehydrogenase and possessed previously unrecognized glutathione reductase (GR) activity, whereas AIF3 lost GR and NAD(P)H dehydrogenase activities