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Dopamine agonists, including pramipexole, provide comparable efficacy but increase the risk of impulse control disorders [262]

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This suggests the possibility of post-transcriptional regulation of GS by ATRA but this remains to be examined

ROS and oxidatively modified macromolecules function as damage-associated molecular patterns (DAMPs), engaging pattern recognition receptors (PRRs) on microglia, including Toll-like receptors (TLRs) and NOD-like receptors (NLRs), to initiate inflammatory cascades ( Microglia, the resident immune cells of the CNS, are tightly regulated under physiological conditions to maintain neural homeostasis