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Well, Ben, thank you so much

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IFN- triggers an intracellular signalling pathway in the mitochondria called the itaconate pathway

However, numerous studies have reported that increased intestinal permeability often precedes the onset of T1D-associated symptoms suggesting that disruption of gut barrier integrity may have an aetiological role in T1D or at least contribute to disease pathogenesis (Meddings et al

Lindley EM, Guerra FA, Krauser JT, Matos SM, Burger EL, Patel VV

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