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10.1016/j.rmed.2008.09.013 [DOI] [PubMed] [Google Scholar] 110.Duca L, Ottolenghi S, Coppola S, Rinaldo R, Dei Cas M, Rubino FM, et al

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Diabetologia 64 , 16261641 (2021)

As the most abundant intracellular thiol antioxidant, GSH is the primary oxidative stress defense of the brain, coordinating synthesis, recycling, and redox signaling to maintain redox homestasis (Schulz et al., 2000)

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In regions of high metabolic activity, such as in the brain, oxidative stress is more likely due to the increased production of free radicals, namely the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS)