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In this stage, intracellular signaling via the Small Mothers of Decapentaplegic (SMAD) phosphorylation pathway begins, with increased expression of hepcidin genes
Oxid Med Cell Longev 2022:3846217 Hou Y, Cai S, Yu S, Lin H (2021) Metformin induces ferroptosis by targeting miR-324-3p/GPX4 axis in breast cancer

Would surmise this has something to do with blood-flow/circulation then

It is not entirely clear if attenuation of ERK1/2 activation is the reason for the loss of the beneficial effects of hypoxic preconditioning

Crohns Colitis 17 , 767776 (2023)

The monocarboxylate transporters MCT1 and MCT4 are highly expressed in glioblastoma and crucially implicated in the pathobiology
