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Studies on TAMs demonstrate that iron-based metal-organic framework nanoparticles combined with ferroptosis inducers enhance TAM resistance to anti-inflammatory factors and activate pro-inflammatory signaling pathways [211]

it induces mitochondrial dysfunction in cholestasis and in ischemia/reperfusion injury

Fructooligosaccharide supplementation alleviated the pathological immune response and prevented the impairment of intestinal barrier in DSS-induced acute colitis mice

First, while we identified IFN-I signaling as a key upstream inducer of Chac2 expression, the precise molecular details by which IFN-I regulates Chac2 transcription and activity require further investigation

Owing to their multi-target and synergistic pharmacological mechanisms, such as anti-inflammatory, membrane-stabilizing, antioxidant, anti-apoptotic, and immunomodulatory effects, they have demonstrated clear efficacy in the clinical treatment of various liver conditions, including viral hepatitis, drug-induced liver injury, and alcoholic liver disease

Leuk Lymphoma 35(5-6):483-9, 1999
