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These findings suggest that the efficacy of GLP-1RA-based anti-obesity treatments may be contingent upon carnitine bioavailability, particularly in populations with restricted dietary intake (e.g., vegans) who rely heavily on the de novo biosynthetic pathway, while also positioning SLC25A45 as a transcriptionally regulated target of thyroid hormone-mediated metabolic adaptation

Cave MC, Hurt RT, Frazier TH, Matheson PJ, Garrison RN, McClain CJ, McClave SA: Obesity, inflammation, and the potential application of pharmaconutrition

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Di Fermo P, Di Lodovico S, Di Campli E, et al
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