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Knocking down the two genes by siRNA also confirmed the sensitivity of G12D and G12V mutant cells to the inhibition of GLS and GS together (Appendix Fig

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Indeed, at micromolar concentrations comparable to those found in human plasma and tissues, 4-HNE has demonstrated antiproliferative, proapoptotic, antiangiogenic, and prodifferentiative effects on various tumor cells in vitro

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