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These synergistic effects were also reflected in vitro (Fig

Purine nucleosides, namely adenosine and guanosine, have relevant neuroprotective roles by acting both centrally and peripherally, via activation of their receptors and intracellular signaling mechanisms [269, 270]
When taking B12 via injections or high doses of supplements, it bypasses the absorption limits of dietary B12, leading to a temporary rise in blood B12 levels

Some poisons can be reabsorbed into the enterohepatic circulation after being excreted in bile

PMID: 36270390

Comprehensive preclinical safety evaluations across multiple animal models demonstrate favorable tolerability profiles with excellent safety margins for investigational research applications
