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The activation of PPAR- upregulates the transcription of acyl-CoA oxidase 1 (ACOX1), and a range of substances, including PFOS, PFOA, PFNA, and PFHxS, can act as the predominant activates of PPAR-, interfering with peroxisomal -oxidation, leading to hepatocyte mitochondrial damage and lipid accumulation [76, 77]

[DOI] [PubMed] [Google Scholar] 162.Dai M., Song C.W., Yang Y.J., Kim H.R., Reo Y.J., Ahn K.H

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Nature 412 , 346351 (2001)

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An assortment of epidemiological and clinical studies have stated glucose and lipid metabolism alterations, insulin resistance, and central obesity as predominant factors for the development of MetS [38, 212]