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This changes the peptide's structure and how it interacts with cell receptors, leading to possible variations upon comparing the effects of GHK-Cu vs AHK-Cu on the body

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When administered, it helps the body produce more of its natural hormone

Phase 2 trial data (Jastreboff et al., NEJM 2023) demonstrated average weight reductions of approximately 1724% over 48 weeks notably higher than currently approved GLP-1 receptor agonists such as semaglutide, though direct comparisons are limited by differences in trial populations and designs

The 24-week trials allowed for assessment of several long-term safety considerations

Specifically, alkylation of a C3-amino-quinoline derived precursor, such ascompound8, may be achieved via reductive amination with, for example, triethyl orthoformate in TFA followed by treatment with NaBH 4 to give the corresponding secondary C3-amine derivative (such as N-methyl-C3-amino-quinoline 9)