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Semaglutide and GLP-1 medications mimic hormone receptor agonists known as glucagon-like peptide-1 agonists

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations CS, chondroitin sulfate

10.1016/j.cell.2009.12.053 21 LiuW

As such, the association with efficacy may be the result of enhanced trafficking of the protein within the cell that ultimately modulates the cell surface abundance of the receptor, rather than the result of alterations in the receptor protein structure that may influence ligand affinity