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the retentate was collected by centrifugation at 1000 g for 5 min at 4 C

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Mechanistically, the majority of senolytics induce senolysis by targeting and inhibiting of senescence cell antiapoptotic pathways (SCAPs), among which are ephrin-B 1/3 (EFNB1/3), p53, the heat shock protein 90 (HSP90), and anti-apoptotic members of B-cell lymphoma-2 (BCL-2) family proteins, such as BCL-extra large (BCL-xL) and BCL-w

10.3390/nu10081038 28

Fecal transplantation was used to determine whether the anti-atherosclerotic effect of formononetin was mediated by modulation of the gut microbiota

N.Pedraza-ChaverriJ