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This progression from CKD to ESRD has been observed in patients undergoing Hemodialysis (HD) [146,147]

Saiki and colleagues identified marker genes for the differential diagnosis of CFS i.e., the expression of GZMA , PSMA3 , PSMA4 , COX5B , ATP5J2 , and DB1 was decreased while the expression of STAT5A was upregulated in CFS individuals (Saiki et al

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This is consistent with the phase 2b clinical trial, where the total 12-week result was 2.8kg (6.2 lbs) additional fat loss versus placebo (clinical trial data)

10.3389/fendo.2021.683151 13 CobbL

Bar-Or D, Kulig K, Marx JA et al