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Oral B12 supplementation may be appropriate in specific circumstances: Dietary deficiency in individuals with normal absorption capacity (typically 50-150 micrograms daily) Patient preference (after discussion of relative efficacy) Maintenance therapy in selected cases Higher oral doses (10002000 micrograms daily) may be used in some cases, as only a small percentage is absorbed through passive diffusion when intrinsic factor-mediated absorption is impaired

Secondary Plasma Amino Acids The levels of secondary (non-proteinogenic) plasma amino acids are given in Table 9

1419), stable in human gastric juice, accordingly investigated in trials for inflammatory bowel disease, wound treatment, with no toxicity reported, where LD1 could be not achieved, effective alone without carrier (5-7, 9)

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