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Transferrin receptor (CD71) is a marker of poor prognosis in breast cancer and can predict response to tamoxifen

Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2

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As a result, using a pleiotropic medication that affects distinct cancer cell properties could be a viable method to fight glioblastoma [284]

However, further studies are still needed to optimize its clinical application, including dosage form improvement, combination therapy strategies and long-term safety assessment