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A oligomer toxicity studies in primary cortical neuron cultures further supported these findings

Cells regulate the production and degradation of proteins in a coordinated manner to maintain cellular homeostasis and adapt to the constantly changing environmental conditions throughout the day

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Mass spectrometric analysis showed that copper ionophore treatment led to iron-sulfur cluster protein loss and subsequent proteotoxic stress in an FDX1-dependent manner, further emphasizing the interaction between FDX1, protein lipoylation machinery, and copper toxicity [3]