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The supplement did not contain lipoic acid, and it did not affect levels of lipoic acid, so it appears that children were more likely to improve if they already had sufficient lipoic acid, whereas a lower level of lipoic acid seemed to be associated with less improvement

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METAOD006 was a 24-week, randomized, double-blind, placebo-controlled, multicenter Phase 2b study that enrolled around 500 clinically obese adults, randomized to daily oral doses of AOD-9604 (0.25, 0.5, or 1 mg) or placebo, on a background diet-and-exercise regimen