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The latter plays a key role in the genetic transcription of the glucose transporter (GLUT 1) and the glycolysis enzymes, as well as in the inhibition of pyruvate dehydrogenase (PDH) with reduction of pyruvate conversion to acetyl-CoA and subsequent inhibition of Krebs cycle or oxidative phosphorylation [91,92]

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The Phase 2 obesity trial published in the New England Journal of Medicine reported substantial weight reduction over 48 weeks, while a separate Phase 2 trial in people with type 2 diabetes evaluated glycemic and body-weight effects

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