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The regulatory effect of lactate on the NLRP3 inflammasome exhibits a significant double-edged sword characteristic, meaning that in different pathological contexts, lactate can either promote or inhibit NLRP3 activation through distinct molecular mechanisms
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CircTRIM1 encodes TRIM1-269aa to promote chemoresistance and metastasis of TNBC via enhancing CaM-dependent MARCKS translocation and PI3K/AKT/mTOR activation
The combination of CB-839 and 5-FU resulted in significant regression of CRC in PIK3CA mutant xenografted nude mouse models (89)
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