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NRF2 regulating the antioxidant stress response NRF2 is a crucial nuclear transcription factor that plays a key role in cellular antioxidant defense and protection

One of these is reduced activity of -ketoglutarate dehydrogenase, which leads to an energy deficit due to deterioration of the tricarboxylic acid cycle and reduced ATP synthesis, in addition to decreased activity of the Na+/K+ATPase, resulting in high toxicity, activation of glutamate receptor, calcium input, and finally, neuronal death.[46] Findings show that vitamin B-1 deficiency is tied to neuro-inflammation, which plays a key role in AD pathogenesis

2.2 Impairment of the CAN network conductance pathway triggers increased SN tension Ischemia in some key regions is more likely to trigger cardiac damage, which is closely related to brain regions associated with the ANS projection loop

Zhao J, Qin L, Song R, Su J, Yuan Y, Zhang X, Mao S