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Whereas the other commonly used antidepressants for neuropathic pain (e.g., tricyclic antidepressants) are associated with a distinctive risk for QT prolongation, only a high TRZ dosage affects the QT interval [29]

However, other studies found increased CSF permeability and BBB disruption in a subset of patients infected with SARS-CoV-2 with elevated Q-albumin ratios that correlated with markers of inflammation 64

Studies have shown increased fat oxidation and energy expenditure following administration

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