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References: Anna Loewa et al., Human disease models in drug development

doi: 10.1016/j.enzmictec.2020.109621 15 DelacuvellerieA.CyriaqueV.GobertS.BenaliS.WattiezR

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is subject to confounding by hospital (treatment highly dependent on the hospital, different SOC/ICU transfer practices, not included in PS), immortal time (only partly addressed in sensitivity analysis), co-treatment differences, calendar-time (SOC evolved rapidly early in the pandemic), binary coding for age (age 65 despite steep age-risk gradient), residual imbalance (variables dropped from PS), a composite outcome dependent on hospital triage/capacity, and other factors