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This has clinical significance because, in general, the volume of a stroke correlates with severity and the resultant degree of disability of the patient [7, 8]

J.MaruyamaY.FishwickK.VrljicakP.TewaryS.FujiharaR.et al (2017)

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In summary, iron is involved in multiple steps across gene regulation, from DNA synthesis, replication, and repair, and epigenetic control, to certain transcription factors related to circadian maintenance, mRNA processing and translation