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What was the early development failure of cagrilintide, and how was it overcome

doi: 10.3389/fnagi.2024.1428244 Received 06 May 2024 Accepted 24 July 2024 Published 05 August 2024 Volume 16 - 2024 Edited by Yuan Li, University of Copenhagen, Denmark Reviewed by Keiichi Kadoyama, Himeji Dokkyo University, Japan Costas E

Introduction Cancers of the digestive system comprise hepatocellular carcinoma (HCC), gastric, pancreatic, esophageal, and colorectal cancers (CRCs) and have been reported to result in high morbidity and mortality all over the world (Zhang H

So, in summary: FOXO4-DRI appears to represent the next-generation senolytic, offering improved specificity, but it is still earlier stage than many small-molecule senolytics or repurposed drug combinations