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Fecal microbiota transplantation (FMT) from healthy donors to individuals diagnosed with metabolic syndrome, delivered via duodenal infusion, has been shown to alter the gut microbial profile of recipients and enhance insulin sensitivity (134)

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Gioia, C., Lucchino, B., Tarsitano, M

Oral formulations may require longer durations given the bioavailability uncertainty
10.1038/s41401-021-00726-0 28 LiY.de HaarC.ChenM.DeuringJ.GerritsM

Expression of Claudin1 (CLDN1) has been shown to be increased in both high-grade dysplasia and ulcerative colitis-associated CRC tissue when compared to ulcerative colitis and normal tissue (95)