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doi: 10.1183/13993003.00646-2019 211 ChenCGuoQLiuYHouQLiaoMGuoYet al

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Abnormalities in the sphingolipid metabolism pathway may also contribute to changes in the reactive state of astrocytes, contributing to their pathogenicity in MS in an NFkB-dependent manner (109)

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It seems that the increase in Nrf-2 and its targets HO-1 and MRP-3 might be the specific signature of DR-related Nrf-2 pathway activation

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