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Compared with our previous case report, in this article the antioxidant therapy is significantly enhanced, in fact in all three cases new antioxidant substances have been added (L-carnitine, coenzyme Q-10, Boswellia) and specifically in cases 2 and 3, we increased the dosages of two substances (propolis from 600 to 700 mg and bilberry from 160 to 180 mg), and we also added other substances (vitamin C 50 mg + superoxide dismutase 11,000 IU), which allowed us to significantly reduce the dosage of vitamin E

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Frye RE, Melnyk S, MacFabe DF (2013) Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder

Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]

Childrens autism metabolome project participants The Childrens Autism Metabolome Project (CAMP, ClinicalTrials.gov Identifier: NCT02548442) study enrolled 1,102 children, ages 1848 months, across 8 clinical sites from August, 2015 through January, 2018