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Secreted factors from intervertebral disc cells and infiltrating macrophages promote degenerated intervertebral disc catabolism
A gastric pentadecapeptide studied extensively for its interaction with tendon, ligament, muscle, and joint signaling pathways

The clinical dosage range spans 2.510 mg per subcutaneous injection, titrated over 4 weeks before reaching a maintenance dose of 510 mg, five times weekly

doi: 10.3389/fpsyg.2025.1641693 Received 06 June 2025 Accepted 19 August 2025 Published 09 September 2025 Volume 16 - 2025 Edited by Mark Antoniou, Western Sydney University, Australia Reviewed by Alexandra Wolf, RIKEN Center for Advanced Intelligence Project (AIP), Japan Lifeng Tang, Ningbo Rehabilitation Hospital, China Updates Copyright 2025 Maggio, Maione, Cotelli, Bonasera, Corallo, Pistorino, Luca, Marra, Quartarone, Nicoletti and Calabr