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PMID: 39233830, PMCID: PMC11372298, DOI: 10.1093/noajnl/vdae142

Mechanistically, hypoxic/glycolytic tumor niches boost glucose metabolism in CD71 + neutrophils, leading to increased lactate production and subsequent histone lactylation, but not histone acetylation, at the Arg1 promoter, resulting in T cell suppression

NNMT is expressed at high levels in the liver and is also present in adipose tissue, kidney, brain, lung, heart, and skeletal muscle

Any deficiencies, dysbiosis, or other issues identified via functional lab testing should be addressed, along with associated conditions that may contribute to histamine intolerance

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Suzuki et al